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pentobarbital will lower the level or influence of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.pentobarbital improves effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Check. Coadministration of ifosfamide with CYP2B6 inducers might raise metabolism of ifosfamide